제목 : A failure of suppression within the default mode network in depressed adolescents with compulsive internet game play
저자 : Doug Hyun Han, Sun Mi Kim, Sujin Bae, Perry F. Renshaw, Jeffrey S. Anderson
초록 :
Background
Individuals who are chronic, compulsive video game players experience an elevated incidence of major depression. Excessive or problematic game play can interact with depression clinically, and may magnify impulsive behavior associated with video gaming.
Methods
Functional brain imaging was performed during a Wisconsin Card Sorting Test (WCST) task in 42 healthy control and 95 volunteers seeking treatment for compulsive video game playing, including 60 participants without major depression (pure internet gaming disorder, pure IGD) and 35 participants comorbid with major depression (IGD+MDD).
Results
In response to the WCST in contrast to fixation, activation was observed in canonical brain attentional networks including bilateral intraparietal sulcus, frontal eye fields, and middle temporal cortical regions as well as dorsolateral prefrontal, inferior parietal and anterior insula, anterior cingulate cortex in all participants. For WCST>Fixation contrasts, the IGD+MDD group exhibited greater relative activation within the left hippocampus, compared to healthy control participants. For WCST>Fixation contrasts, the IGD+MDD group exhibited greater relative activation within the left hippocampus and the right parahippocampal gyrus immediately posterior to the hippocampus, compared to the pure IGD group.
Conclusions
In cohorts of individuals with a history of compulsive internet game play, individuals with depression showed failure to suppress default mode network activity during an attentionally demanding task, compared to individuals without depression, including comparison groups with and without a history of compulsive video gaming. This reduced suppression of the brain regions within the default mode network may be a consequence of depressive neurophysiology or represent a predisposition for depression within compulsive game players.
URL : https://www.sciencedirect.com/science/article/abs/pii/S0165032715311101?casa_token=d-56Hgihzy0AAAAA:VESbJmerLvMcyTPtIdd2ak4ILZY4fecXoSNRJrdxjEcUGZKlQDXG-tj7gOkve-9jo6zitSThmw
제목 : A failure of suppression within the default mode network in depressed adolescents with compulsive internet game play
저자 : Doug Hyun Han, Sun Mi Kim, Sujin Bae, Perry F. Renshaw, Jeffrey S. Anderson
초록 :
Background
Individuals who are chronic, compulsive video game players experience an elevated incidence of major depression. Excessive or problematic game play can interact with depression clinically, and may magnify impulsive behavior associated with video gaming.
Methods
Functional brain imaging was performed during a Wisconsin Card Sorting Test (WCST) task in 42 healthy control and 95 volunteers seeking treatment for compulsive video game playing, including 60 participants without major depression (pure internet gaming disorder, pure IGD) and 35 participants comorbid with major depression (IGD+MDD).
Results
In response to the WCST in contrast to fixation, activation was observed in canonical brain attentional networks including bilateral intraparietal sulcus, frontal eye fields, and middle temporal cortical regions as well as dorsolateral prefrontal, inferior parietal and anterior insula, anterior cingulate cortex in all participants. For WCST>Fixation contrasts, the IGD+MDD group exhibited greater relative activation within the left hippocampus, compared to healthy control participants. For WCST>Fixation contrasts, the IGD+MDD group exhibited greater relative activation within the left hippocampus and the right parahippocampal gyrus immediately posterior to the hippocampus, compared to the pure IGD group.
Conclusions
In cohorts of individuals with a history of compulsive internet game play, individuals with depression showed failure to suppress default mode network activity during an attentionally demanding task, compared to individuals without depression, including comparison groups with and without a history of compulsive video gaming. This reduced suppression of the brain regions within the default mode network may be a consequence of depressive neurophysiology or represent a predisposition for depression within compulsive game players.
URL : https://www.sciencedirect.com/science/article/abs/pii/S0165032715311101?casa_token=d-56Hgihzy0AAAAA:VESbJmerLvMcyTPtIdd2ak4ILZY4fecXoSNRJrdxjEcUGZKlQDXG-tj7gOkve-9jo6zitSThmw